This NOFO supports integrated viral hepatitis surveillance and prevention programs in states, territories, and large cities in the United States. Key strategies include viral hepatitis outbreak response and surveillance for hepatitis A, acute and chronic hepatitis B, and acute, chronic, and perinatal hepatitis C. Surveillance activities include developing and utilizing disease registries, conducting data matching, generating data summaries, utilizing data to monitor program progress and inform program activities and to enhance case investigations for data-to-care opportunities, and strengthening health department infrastructure to expand surveillance capacity. Prevention activities include supporting viral hepatitis elimination planning, partnerships, and coordination in high-impact and healthcare settings, increasing hepatitis B and hepatitis C testing, treatment, and service integration in high-impact settings, and developing perinatal hepatitis C programs. Expected outcomes include improved surveillance and reporting of viral hepatitis, improved strategic planning and partner collaboration in viral hepatitis elimination, and expanded access to viral hepatitis prevention, diagnosis, and treatment in high-impact settings.