The purpose of this NOFO is to enhance the capability of NCATS CTSA Program KL2 scholars supported by the CTSA Program to conduct research as they complete the transition to fully independent academic translational scientists. These small research grants will support different clinical and translational science research projects, including pilot and feasibility studies; secondary data analysis of existing data; small, self-contained research projects; development of research methodology; and development of new research technology. Research proposed in the application may or may not include patient-oriented research. This small research grant is, therefore, intended to support research projects that can be carried out in a short period of time with limited resources and that provide preliminary data to support submission of a subsequent research project grant, or equivalent, application.