The purpose of this funding opportunity is to support mechanistic research to understand how exposure to metals and metal-containing compounds alters biological processes relevant to human health. Of particular interest are studies that elucidate the absorption, distribution, transport, cellular trafficking, biological interactions, and mechanisms of action of metals, including mechanisms through which metals may alter immune homeostasis, cross the placental barrier, or gain access to and affect the central nervous system. Studies may employ experimental models, new approach methodologies, computational approaches, or leverage human biospecimens where these approaches are used to address defined mechanistic hypotheses.

Government

• City or township governments
• State governments
• Public and Indian housing authorities
• Special district governments
• County governments
• Federally recognized Native American tribal governments

Business

• For-profit organizations other than small businesses
• Small businesses

Miscellaneous

• Other

Education

• Public and state institutions of higher education
• Independent school districts
• Private institutions of higher education

Nonprofit

• Nonprofits non-higher education with 501(c)(3)
• Other Native American tribal organizations
• Nonprofits non-higher education without 501(c)(3)