Cellular Senescence Network (SenNet): SenNet Technology Projects (SenTecs) (UG3/UH3 Clinical Trial Not Allowed)
Agency: National Institutes of Health
Assistance Listings: 93.310 -- Trans-NIH Research Support
Last Updated: October 9, 2026
Description
The purpose of this Notice of Funding Opportunity (NOFO) is to solicit the development of innovative senescence technologies (SenTecs), or the adaptation of existing technologies focused on identification, characterization and understanding the biological consequences of senescent cell (SnC) heterogeneity in the context of the tissue environments and secretomes to facilitate novel strategies for modulating SnCs in vivo and for predicting the outcomes of targeting SnCs in human aging and in disease conditions. These are five-year, milestone-driven awards consisting of two phases. The first two...
years constitute the UG3 phase and are focused on SenTec development and demonstration of technology feasibility. The following 3-years is the SenTec application UH3 phase where SenTecs continue to be optimized, refined and validated. In the final year of the UH3 award, SenTecs will undertake a demonstration project conducted in a collaborative effort within SenNet to provide further validation of the proposed SenTec. Applicants are required to submit both UG3 and UH3 projects together when responding to this NOFO. Transition from the UG3 to UH3 phases is not automatic and will occur only after administrative review of each SenTec at the close of Year 2 of the award.
Eligibility
Eligible applicants
Education
- Public and state institutions of higher education
- Private institutions of higher education
- Independent school districts
Government
- Public and Indian housing authorities
- State governments
- County governments
- City or township governments
- Special district governments
- Federally recognized Native American tribal governments
Miscellaneous
- Other
Nonprofit
- Nonprofits non-higher education with 501(c)(3)
- Other Native American tribal organizations
- Nonprofits non-higher education without 501(c)(3)
Business
- For-profit organizations other than small businesses
- Small businesses
Additional information
Other Eligible ApplicantsIndian/Native American Tribal Governments (Other than Federally Recognized);Eligible Agencies of the Federal Government;U.S. Territory or Possession;Faith-based or Community-based Organizations;Regional Organizations;Non-domestic (non-U.S.) Entities (Foreign Institutions).
Grantor contact information
Description
Common Fund Cellular Senescence Program
CS2@nih.gov
Inbox for the Common Fund Cellular Senescence Program
Documents
| File name | Description | Last updated |
|---|---|---|
| RFA-RM-27-007-Full-Announcement.html | RFA-RM-27-007-Full-Announcement.html | Oct 9, 2026 05:04 PM UTC |
Link to additional information
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Closing: November 23, 2026
Award
$6,000,000
Program Funding
15
Expected awards
$--
Award Minimum
$--
Award Maximum
Funding opportunity number:
RFA-RM-27-007
Cost sharing or matching requirement:
No
Funding instrument type:
Cooperative agreement
Opportunity Category:
Discretionary
Opportunity Category Explanation:
--
Category of Funding Activity:
Health
Category Explanation:
--
History
Version:
1
Posted date:
October 9, 2026
Archive date:
January 22, 2027
