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Causal Hypotheses on the Oral-Systemic Health Impacts of Human Behaviors among People with Chronic Conditions

Agency: National Institutes of Health

Assistance Listings: 93.121 -- Oral Diseases and Disorders Research

Last Updated: July 29, 2025

Description

The National Institute of Dental and Craniofacial Research (NIDCR) intends to publish a Notice of Funding Opportunity (NOFO) to solicit applications for innovative research on the factors that cause human behaviors and the oral-systemic health impacts of those behaviors to enhance health, lengthen life, and reduce illness and disability among people with chronic conditions. Causal hypotheses may include biological, biopsychosocial, congenital, environmental, interpersonal, neurological, psychological, and comorbidity factors that—individually, sequentially, or in combination—contribute to human behaviors and oral-systemic health outcomes, with impacts that may be direct or traceably distal. Applications that propose projects to develop or refine causal hypotheses, e.g., causal explanation and causal inference—rather than statistical association, also are encouraged. Project results should be poised for clinical trials translation to prevent, treat, and manage dental, oral, and craniofacial (DOC) and related conditions. Applications are not being solicited at this time. Notice is being provided to allow potential applicants sufficient time to develop meaningful collaborations and responsive projects. Investigators with expertise and insights into this area of behavioral, biological, biopsychosocial, public, and social sciences are encouraged to consider applying for this new NOFO. In addition, collaborative investigations combining expertise in dental, oral, craniofacial, and systemic health over the life course, including care and services, will be encouraged, and these investigators also should begin to consider applying. NIDCR is authorized to forecast this opportunity under the Public Health Service Act (42 U.S.C §§ 241 and 284) and federal regulations (42 CFR Part 52 and 2 CFR Part 200).

Eligibility

Eligible applicants

Education

  • Independent school districts
  • Private institutions of higher education
  • Public and state institutions of higher education

Government

  • County governments
  • Federally recognized Native American tribal governments
  • Public and Indian housing authorities
  • State governments

Nonprofit

  • Nonprofits non-higher education with 501(c)(3)
  • Other Native American tribal organizations

Business

  • Small businesses
  • For-profit organizations other than small businesses

Additional information

Grantor contact information

Description

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Email

william.elwood@nih.gov

william.elwood@nih.gov

Documents

No documents are currently available.

Link to additional information

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Forecasted

Estimated Post Date:

March 2, 2026

Estimated Application Due Date:

June 5, 2026

Estimated Due Date Description:

Not available

Estimated Award Date:

April 1, 2027

Estimated Project Start Date:

April 1, 2027

Fiscal Year:

2027

Application process

This site is a work in progress. Go to www.grants.gov to apply, track application status, and subscribe to updates.

Award

$--

Program Funding

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Expected awards

$--

Award Minimum

$--

Award Maximum

Funding opportunity number:

FOR-DE-26-004

Cost sharing or matching requirement:

No

Funding instrument type:

Cooperative agreement

Opportunity Category:

Discretionary

Opportunity Category Explanation:

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Category of Funding Activity:

Health

Category Explanation:

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History

Version:

1

Forecast posted date:

July 29, 2025

Archive date:

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