Centers for Precision Disease Modeling (U54) (Clinical Trials Not Allowed)
Agency: National Institutes of Health
Assistance Listings
- 93.351 -- Research Infrastructure Programs
Archived opportunityLast Updated: May 13, 2026
View version history on Grants.gov
Description
This Notice of Funding Opportunity (NOFO) invites U54 cooperative agreement applications for the support and advancement of the Centers for Precision Disease Modeling. The goal of the Centers is to support collaborative research projects that bridge current personalized medicine efforts in human subjects with advances in animal genomics and genetic manipulation technologies, including the creation of interspecies somatic hybrids. By functionally linking these areas of research, the Centers aim to enhance the predictive value of preclinical studies through the use of precision animal models. Each...
Center will develop a process by which the research community can nominate unique human genomic variants for cost effective high-throughput testing in an animal model pipeline. After validation of the expected gene editing, the Centers will support assays to conduct comprehensive functional and phenotyping analyses to evaluate disease-causing variants. A key mission of the Centers is the creation and distribution of precision animal model resources and related services to the biomedical community. Therefore, Centers will establish pipelines for preclinical scientific discovery, disease modeling, and development of interventions based on innovative animal models. While the Centers will focus on a limited number of targeted projects, they are expected to develop and maintain multifaceted research activities that can be adjusted to accommodate a wide range of diseases.
Eligibility
Eligible applicants
Government
- Special district governments
- Public and Indian housing authorities
- County governments
- State governments
- Federally recognized Native American tribal governments
- City or township governments
Miscellaneous
- Other
Nonprofit
- Other Native American tribal organizations
- Nonprofits non-higher education with 501(c)(3)
- Nonprofits non-higher education without 501(c)(3)
Education
- Public and state institutions of higher education
- Independent school districts
- Private institutions of higher education
Business
- Small businesses
- For-profit organizations other than small businesses
Additional information
Other Eligible Applicants include the following:
Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession; Non-domestic (non-U.S.) Entities (Foreign Organization) are not eligible to apply.
Non-domestic (non-U.S.) components of U.S. Organizations are not eligible to apply.
Foreign components, as defined in the NIH Grants Policy Statement, are not allowed.
Grantor contact information
Description
NIH Grants Information
grantsinfo@nih.gov
See Section VII. Agency Contacts within the full opportunity announcement for all other inquires.
Documents
| File name | Description | Last updated |
|---|---|---|
| PAR-24-305-Full-Announcement.html | PAR-24-305 Full Announcement Text | Oct 7, 2024 01:28 PM UTC |
Link to additional information
https://grants.nih.gov/grants/guide/pa-files/PAR-24-305.html
Archived: January 20, 2025
Award
$--
Program Funding
--
Expected awards
$--
Award Minimum
$--
Award Maximum
Funding opportunity number:
PAR-24-305
Cost sharing or matching requirement:
No
Funding instrument type:
Cooperative agreement
Opportunity Category:
Discretionary
Opportunity Category Explanation:
--
Category of Funding Activity:
Health
Category Explanation:
--
History
Version:
1
Posted date:
October 4, 2024
Archive date:
January 20, 2025
