This Notice of Funding Opportunity (NOFO) solicits applications that propose to conduct time-sensitive ancillary studies in conjunction with privately or publicly funded, active, ongoing clinical projects (parent projects). The parent project can be an interventional clinical trial, or a clinical study such as an observational study, or a disease-specific repository that will be actively collecting patient samples or clinical data. The parent project(s) should provide a cohort of well-characterized patients, infrastructure, data, and biological samples for the ancillary study. The objective of this NOFO is to provide a flexible mechanism to leverage currently funded resources and maximize the return on existing investments in parent projects. Successful ancillary studies will enhance the scientific content and value of the parent projects, improve the research community’s understanding of a disease or organ system and thus may identify novel targets for diagnosis, treatment, and prevention of disease.

Government

• Federally recognized Native American tribal governments
• Special district governments
• State governments
• County governments
• City or township governments
• Public and Indian housing authorities

Education

• Independent school districts
• Private institutions of higher education
• Public and state institutions of higher education

Nonprofit

• Other Native American tribal organizations
• Nonprofits non-higher education with 501(c)(3)
• Nonprofits non-higher education without 501(c)(3)

Business

• For-profit organizations other than small businesses
• Small businesses

Miscellaneous

• Other