INCLUDE Project: Transformative Research Awards for Down syndrome (R01 Clinical Trial Not Allowed)
Agency: National Institutes of Health
Assistance Listings
- 93.310 -- Trans-NIH Research Support
- 93.867 -- Vision Research
- 93.866 -- Aging Research
- 93.847 -- Diabetes, Digestive, and Kidney Diseases Extramural Research
- 93.840 -- Translation and Implementation Science Research for Heart, Lung, Blood Diseases, and Sleep Disorders
- 93.846 -- Arthritis, Musculoskeletal and Skin Diseases Research
- 93.173 -- Research Related to Deafness and Communication Disorders
- 93.837 -- Cardiovascular Diseases Research
- 93.855 -- Allergy and Infectious Diseases Research
- 93.351 -- Research Infrastructure Programs
- 93.839 -- Blood Diseases and Resources Research
- 93.350 -- National Center for Advancing Translational Sciences
- 93.395 -- Cancer Treatment Research
- 93.121 -- Oral Diseases and Disorders Research
- 93.865 -- Child Health and Human Development Extramural Research
- 93.242 -- Mental Health Research Grants
- 93.838 -- Lung Diseases Research
- 93.879 -- Medical Library Assistance
- 93.233 -- National Center on Sleep Disorders Research
Open opportunityLast Updated: May 13, 2026
View version history on Grants.gov
Description
The NIH INvestigation of Co-occurring conditions across the Lifespan to Understand Down syndromE (INCLUDE) Project seeks to improve health and quality-of-life for individuals with Down syndrome. The purpose of this Notice of Funding Opportunity (NOFO) is to solicit Transformative Research Award applications to support individual scientists or groups of scientists proposing groundbreaking, exceptionally innovative, original, and/or unconventional research that has the potential to create new scientific paradigms, establish entirely new and improved clinical approaches, or develop transformative technologies...
related to Down syndrome. Applications are welcome in all topics relevant to Down syndrome-related research or its co-occurring conditions. No preliminary data are required. Projects must clearly demonstrate, based on the strength of the logic, a compelling potential to produce a major impact in research related to Down syndrome.
Eligibility
Eligible applicants
Government
- County governments
- Federally recognized Native American tribal governments
- City or township governments
- Public and Indian housing authorities
- State governments
- Special district governments
Education
- Public and state institutions of higher education
- Private institutions of higher education
- Independent school districts
Nonprofit
- Nonprofits non-higher education with 501(c)(3)
- Nonprofits non-higher education without 501(c)(3)
- Other Native American tribal organizations
Miscellaneous
- Other
Business
- For-profit organizations other than small businesses
- Small businesses
Additional information
Refer to Section III. Eligibility Information in the NOFO for additional information on eligibility.Foreign Organizations/International Collaborations:Non-domestic (non-U.S.) Entities (Foreign Organizations) are eligible to apply.Non-domestic (non-U.S.) components of U.S. Organizations are eligible to apply.Foreign components, as defined in the NIH Grants Policy Statement, are allowed.
Grantor contact information
Description
The INCLUDE Project
DownSyndromeINCLUDE@mail.nih.gov
DownSyndromeINCLUDE@mail.nih.gov
Documents
| File name | Description | Last updated |
|---|---|---|
| RFA-OD-27-004-Full-Announcement.html | RFA-OD-27-004-Full-Announcement.html | May 12, 2026 04:17 PM UTC |
Link to additional information
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Closing: June 15, 2028
Award
$3,000,000
Program Funding
4
Expected awards
$--
Award Minimum
$500,000
Award Maximum
Funding opportunity number:
RFA-OD-27-004
Cost sharing or matching requirement:
No
Funding instrument type:
Grant
Opportunity Category:
Discretionary
Opportunity Category Explanation:
--
Category of Funding Activity:
Health
Category Explanation:
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History
Version:
1
Posted date:
May 12, 2026
Archive date:
August 14, 2028
