Opportunity Listing - INCLUDE Project: Transformative Research Awards for Down syndrome (R01 Clinical Trial Not Allowed)

INCLUDE Project: Transformative Research Awards for Down syndrome (R01 Clinical Trial Not Allowed)

Agency: National Institutes of Health

Assistance Listings: 93.310 -- Trans-NIH Research Support

93.867 -- Vision Research

93.866 -- Aging Research

93.847 -- Diabetes, Digestive, and Kidney Diseases Extramural Research

93.840 -- Translation and Implementation Science Research for Heart, Lung, Blood Diseases, and Sleep Disorders

93.846 -- Arthritis, Musculoskeletal and Skin Diseases Research

93.173 -- Research Related to Deafness and Communication Disorders

93.837 -- Cardiovascular Diseases Research

93.855 -- Allergy and Infectious Diseases Research

93.351 -- Research Infrastructure Programs

93.839 -- Blood Diseases and Resources Research

93.350 -- National Center for Advancing Translational Sciences

93.395 -- Cancer Treatment Research

93.121 -- Oral Diseases and Disorders Research

93.865 -- Child Health and Human Development Extramural Research

93.242 -- Mental Health Research Grants

93.838 -- Lung Diseases Research

93.879 -- Medical Library Assistance

93.233 -- National Center on Sleep Disorders Research

Last Updated: May 13, 2026

View version history on Grants.gov

Description

The NIH INvestigation of Co-occurring conditions across the Lifespan to Understand Down syndromE (INCLUDE) Project seeks to improve health and quality-of-life for individuals with Down syndrome. The purpose of this Notice of Funding Opportunity (NOFO) is to solicit Transformative Research Award applications to support individual scientists or groups of scientists proposing groundbreaking, exceptionally innovative, original, and/or unconventional research that has the potential to create new scientific paradigms, establish entirely new and improved clinical approaches, or develop transformative technologies...

related to Down syndrome. Applications are welcome in all topics relevant to Down syndrome-related research or its co-occurring conditions. No preliminary data are required. Projects must clearly demonstrate, based on the strength of the logic, a compelling potential to produce a major impact in research related to Down syndrome.

Eligibility

Eligible applicants

Government

County governments
Federally recognized Native American tribal governments
City or township governments
Public and Indian housing authorities
State governments
Special district governments

Education

Public and state institutions of higher education
Private institutions of higher education
Independent school districts

Nonprofit

Nonprofits non-higher education with 501(c)(3)
Nonprofits non-higher education without 501(c)(3)
Other Native American tribal organizations

Miscellaneous

Other

Business

For-profit organizations other than small businesses
Small businesses

Additional information

Refer to Section III. Eligibility Information in the NOFO for additional information on eligibility.Foreign Organizations/International Collaborations:Non-domestic (non-U.S.) Entities (Foreign Organizations) are eligible to apply.Non-domestic (non-U.S.) components of U.S. Organizations are eligible to apply.Foreign components, as defined in the NIH Grants Policy Statement, are allowed.

Grantor contact information

Description

The INCLUDE Project DownSyndromeINCLUDE@mail.nih.gov

Email

DownSyndromeINCLUDE@mail.nih.gov

Documents

File name	Description	Last updated
RFA-OD-27-004-Full-Announcement.html	RFA-OD-27-004-Full-Announcement.html	May 12, 2026 04:17 PM UTC

Link to additional information

Closing: June 15, 2028

Application process

This site is a work in progress. Go to www.grants.gov to apply, track application status, and subscribe to updates.

Award

$3,000,000

Program Funding

Expected awards

$--

Award Minimum

$500,000

Award Maximum

Funding opportunity number:

RFA-OD-27-004

Cost sharing or matching requirement:

Funding instrument type:

Grant

Opportunity Category:

Discretionary

Opportunity Category Explanation:

Category of Funding Activity:

Health

Category Explanation:

History

Version:

Posted date:

May 12, 2026

Archive date:

August 14, 2028