Opportunity Listing - Screening and Functional Validation of Genomic Variants Associated with Human Congenital Anomalies (R01 Clinical Trial Not Allowed)

Screening and Functional Validation of Genomic Variants Associated with Human Congenital Anomalies (R01 Clinical Trial Not Allowed)

Agency: National Institutes of Health

Assistance Listings: 93.351 -- Research Infrastructure Programs

93.121 -- Oral Diseases and Disorders Research

93.865 -- Child Health and Human Development Extramural Research

Last Updated: November 4, 2024

Description

Rapid advances in genotyping and next generation sequencing technologies have led to the identification of genetic variants that are associated with a wide variety of congenital defects including human congenital anomalies (HCAs), intellectual developmental disabilities (IDDs) and inborn errors of metabolism (IEMs). Large quantities of genomic data collected from pediatric congenital anomalies cohorts are available to the research community through several databases such as the Database of Genotypes and Phenotypes (dbGaP), the Gabriella Miller Kids First Data Resource Portal, the European Genome-Phenome...

Archive and Clinical Genome Resource (ClinGen). The purpose of this initiative is to promote the screening, functional validation and characterization of congenital anomaly-associated genetic variants identified through public facing databases and individual efforts using in-silico tools, appropriate animal models, in vitro systems or multi-pronged approaches. This initiative addresses a challenging gap between identifying sequence variations of potential interest and recognizing which of those variations have functional effects on the phenotype of interest.

Eligibility

Eligible applicants

Education

Independent school districts
Public and state institutions of higher education
Private institutions of higher education

Nonprofit

Other Native American tribal organizations
Nonprofits non-higher education with 501(c)(3)
Nonprofits non-higher education without 501(c)(3)

Miscellaneous

Other

Government

County governments
Special district governments
Federally recognized Native American tribal governments
State governments
Public and Indian housing authorities
City or township governments

Business

For-profit organizations other than small businesses
Small businesses

Additional information

Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession.

Grantor contact information

Description

NIH Grants Information grantsinfo@nih.gov

Email

See Section VII. Agency Contacts within the full opportunity announcement for all other inquires.

grantsinfo@nih.gov

Documents

File name	Description	Last updated
PAR-25-185-Full-Announcement.html	PAR-25-185 Full Announcement Text	Nov 4, 2024 12:53 PM UTC

Link to additional information

https://grants.nih.gov/grants/guide/pa-files/PAR-25-185.html

Closing: January 7, 2028

Application process

This site is a work in progress. Go to www.grants.gov to apply, track application status, and subscribe to updates.

Award

$--

Program Funding

Expected awards

$--

Award Minimum

$--

Award Maximum

Funding opportunity number:

PAR-25-185

Cost sharing or matching requirement:

Funding instrument type:

Grant

Opportunity Category:

Discretionary

Opportunity Category Explanation:

Category of Funding Activity:

Income security and social services

Health

Category Explanation:

History

Version:

Posted date:

October 30, 2024

Archive date:

February 12, 2028