the implementation of surveillance activities that focus on protecting and improving public health globally through strategic planning, policy, strengthening surveillance capacities and systems through partnerships. These surveillance systems should build and improve regional and country capacities to detect, respond, control, and prevent infectious diseases and emerging threats; strengthen border health security; and mitigate public health events of international concern (PHEICs) or other global health issues. The implementing partner(s) will work closely with Ministries of Health, CDC country offices, and other stakeholders to assess existing surveillance systems, identify gaps, and propose solutions to enhance system performance. Activities will include the development and adaptation of protocols, training materials, and guidance documents, as well as the integration of surveillance data into actionable insights for decision-making. The partner will also support cross-sectoral collaboration to address One Health priorities, facilitate the use of innovative tools and technologies, and provide workforce development opportunities to build local capacity. This NOFO aligns with the broader mission of the DGHP to improve global health security by ensuring countries are equipped to prevent, detect, and respond to public health threats effectively. The implementing partner will play a critical role in advancing surveillance systems that contribute to timely interventions and evidence-based policy decisions, ultimately safeguarding public health at national and global levels.