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The Genesis Mission: Transforming Science and Energy with AI

Agency: Office of Science

Assistance Listings: 81.049 -- Office of Science Financial Assistance Program

Last Updated: March 17, 2026

The DOE Office of Science (SC), Office of Critical Minerals and Energy Innovation (CMEI), Office of Environmental Management (EM), Office of Nuclear Energy (NE), Office of Electricity (OE), and Hydrocarbons and Geothermal Office (HGEO) hereby announce interest in receiving applications from interdisciplinary teams addressing the Genesis Mission National Science and Technology Challenges to accelerate scientific discovery and research and development (R&D) workflows using novel artificial intelligence (AI) models and frameworks. By achieving AI advantage, these teams will advance the DOE's mission and ensure America’s security and prosperity by addressing energy, environmental, and nuclear challenges through science and technology. Teams are encouraged to leverage the extensive scientific and data resources of the DOE/National Nuclear Security Administration (NNSA), the National Laboratories, U.S. industry, and academia. The resulting AI models and workflows, if successful, may be integrated into the American Science Cloud.

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Eligibility

Eligible applicants

Miscellaneous

  • Unrestricted

Additional information

Grantor contact information

Description

GenesisMissionNOFO@science.doe.gov

Email

GenesisMissionNOFO@science.doe.gov

GenesisMissionNOFO@science.doe.gov

Documents

File nameDescriptionLast updated
DE-FOA-0003612.pdf
DE-FOA-0003612
Mar 17, 2026 12:55 PM UTC
Genesis_Mission_Phase_I_Application_Template.xlsx
Phase I Application Template
Mar 17, 2026 01:05 PM UTC
Genesis_Mission_Phase_II_LOI_Template.xlsx
Phase II LOI Template
Mar 17, 2026 01:06 PM UTC

Link to additional information

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Closing: December 17, 2026

Application process

This site is a work in progress. Go to www.grants.gov to apply, track application status, and subscribe to updates.

Award

$293,760,000

Program Funding

--

Expected awards

$500,000

Award Minimum

$5,000,000

Award Maximum

Funding opportunity number:

DE-FOA-0003612

Cost sharing or matching requirement:

Yes

Funding instrument type:

Other

Opportunity Category:

Discretionary

Opportunity Category Explanation:

--

Category of Funding Activity:

Science technology and other research and development

Category Explanation:

--

History

Version:

2

Posted date:

March 17, 2026

Archive date:

March 17, 2027

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