The purpose of this Program Announcement (PAR) is to enable clinical validation of strong candidate biomarkers for neurological diseases and conditions. Specifically, the goal of this PAR is to enable the rigorous validation of biomarker measurements within the clinical population of interest to establish the positive and negative predictive values of the candidate biomarker consistent with FDA guidelines. This PAR assumes that 1) a candidate biomarker has already been identified, 2) detection method technology has already been developed and analytically validated, and 3) the research and/or clinical need and potential context of use has been identified.

Government

• State governments
• County governments
• City or township governments
• Special district governments
• Federally recognized Native American tribal governments
• Public and Indian housing authorities

Education

• Independent school districts
• Public and state institutions of higher education
• Private institutions of higher education

Nonprofit

• Other Native American tribal organizations
• Nonprofits non-higher education with 501(c)(3)
• Nonprofits non-higher education without 501(c)(3)

Business

• For-profit organizations other than small businesses
• Small businesses

Miscellaneous

• Other