The National Institute on Deafness and Other Communication Disorders (NIDCD), National Eye Institute (NEI), National Institute on Aging (NIA), National Institute on Alcohol Abuse and Alcoholism (NIAAA), National Institute of Biomedical Imaging and Bioengineering (NIBIB), Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), National Institute on Drug Abuse (NIDA), National Institute of Mental Health (NIMH), National Institute of Neurological Disorders and Stroke (NINDS), and National Center for Complementary and Integrative Health (NCCIH), intend to reissue RFA-DC-24-001 a Notice of Funding Opportunity (NOFO) to solicit applications. Research on invasive surgical procedures in humans offer the unique opportunity to intracranially record and stimulate neuronal activity within precisely localized brain structures, enabling high-impact human neuroscience investigations. This NOFO seeks exploratory research projects, from newly formed or established multi-disciplinary teams, to understand how dynamic activity of single cells and ensembles of neurons in spatially organized networks gives rise to the internal states we experience as sensations, perceptions, emotions, thoughts, and memories, and to observable motor and social behaviors. The research should be proposed as exploratory research and planning activities to establish feasibility and early-stage development that, if successful, would support, enable, and/or lay the groundwork for a potential, subsequent research project grant applications using invasive neural recording and stimulation technologies in the human brain. Projects should maximize opportunities to conduct innovative in vivo human neuroscience research made available by direct access to the brain from invasive surgical procedures. Projects should employ approaches guided by specified theoretical constructs and by quantitative, mechanistic models where appropriate. 

Government

• Public and Indian housing authorities
• County governments
• Federally recognized Native American tribal governments
• State governments

Business

• For-profit organizations other than small businesses
• Small businesses

Education

• Public and state institutions of higher education
• Independent school districts
• Private institutions of higher education

Nonprofit

• Other Native American tribal organizations
• Nonprofits non-higher education with 501(c)(3)