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BRAIN Initiative: Exploratory Research Opportunities Using Invasive Neural Recording and Stimulating Technologies in the Human Brain (R61 Basic Experimental Studies with Humans Required)

Agency: National Institutes of Health

Assistance Listings: 93.173 -- Research Related to Deafness and Communication Disorders

Last Updated: June 9, 2025

Description

The National Institute on Deafness and Other Communication Disorders (NIDCD), National Eye Institute (NEI), National Institute on Aging (NIA), National Institute on Alcohol Abuse and Alcoholism (NIAAA), National Institute of Biomedical Imaging and Bioengineering (NIBIB), Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), National Institute on Drug Abuse (NIDA), National Institute of Mental Health (NIMH), National Institute of Neurological Disorders and Stroke (NINDS), and National Center for Complementary and Integrative Health (NCCIH), intend to reissue RFA-DC-24-001 a Notice of Funding Opportunity (NOFO) to solicit applications. Research on invasive surgical procedures in humans offer the unique opportunity to intracranially record and stimulate neuronal activity within precisely localized brain structures, enabling high-impact human neuroscience investigations. This NOFO seeks exploratory research projects, from newly formed or established multi-disciplinary teams, to understand how dynamic activity of single cells and ensembles of neurons in spatially organized networks gives rise to the internal states we experience as sensations, perceptions, emotions, thoughts, and memories, and to observable motor and social behaviors. The research should be proposed as exploratory research and planning activities to establish feasibility and early-stage development that, if successful, would support, enable, and/or lay the groundwork for a potential, subsequent research project grant applications using invasive neural recording and stimulation technologies in the human brain. Projects should maximize opportunities to conduct innovative in vivo human neuroscience research made available by direct access to the brain from invasive surgical procedures. Projects should employ approaches guided by specified theoretical constructs and by quantitative, mechanistic models where appropriate. 

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Eligibility

Eligible applicants

Government

  • Public and Indian housing authorities
  • County governments
  • Federally recognized Native American tribal governments
  • State governments

Business

  • For-profit organizations other than small businesses
  • Small businesses

Education

  • Public and state institutions of higher education
  • Independent school districts
  • Private institutions of higher education

Nonprofit

  • Other Native American tribal organizations
  • Nonprofits non-higher education with 501(c)(3)

Additional information

Grantor contact information

Description

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Email

BRAINeROH@ninds.nih.gov

BRAINeROH@ninds.nih.gov

Documents

No documents are currently available here

Link to additional information

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Forecasted

Estimated Post Date:

August 15, 2025

Estimated Application Due Date:

September 15, 2025

Estimated Due Date Description:

Not available

Estimated Award Date:

June 29, 2026

Estimated Project Start Date:

July 29, 2026

Fiscal Year:

2026

Application process

This site is a work in progress. Go to www.grants.gov to apply, track application status, and subscribe to updates.

Award

$--

Program Funding

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Expected awards

$--

Award Minimum

$--

Award Maximum

Funding opportunity number:

NOT-DC-25-037

Cost sharing or matching requirement:

No

Funding instrument type:

Grant

Opportunity Category:

Discretionary

Opportunity Category Explanation:

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Category of Funding Activity:

Health

Category Explanation:

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History

Version:

1

Forecast posted date:

June 9, 2025

Archive date:

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