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Informatics, Coordination and Service Center for the Mutant Mouse Resource and Research Centers (U42 Clinical Trial Not Allowed)

Agency: National Institutes of Health

Assistance Listings: 93.351 -- Research Infrastructure Programs

Last Updated: June 9, 2025

Description

The Office of Research Infrastructure Programs at Division of Program Coordination, Planning and Strategic Initiatives intends to publish a Notice of Funding Opportunity (NOFO) to solicit applications to provide continuing support for the Informatics, Coordination and Service Center (ICSC) unit of the Mutant Mouse Resource and Research Centers (MMRRC) consortium. The U42 mechanism supports projects to develop and assist animal, biological material and new approach methodologies (NAMs) resources to make models of human diseases available to all qualified investigators without regard to the scientific disciplines or disease orientations of their research activities or specifically directed to a categorical program. This Notice is being provided now to allow potential applicants sufficient time to develop meaningful collaborations and responsive projects.


The NOFO will have two application cycles. The NOFO is expected to be published in Spring 2025, with an expected application due date in Summer 2025. Details of the planned NOFO are provided below.


Research Initiative Details

With this intended reissue of the ICSC funding opportunity, ORIP seeks to enhance ICSC contribution to the larger MMRRC consortium by maintaining scientific rigor, transparency, and experimental reproducibility of the biomedical research while improving the quality of the MMRRC consortium’s services for acquisition, evaluation, characterization, cryopreservation, storage, and distribution of mutant mouse strains and related biological materials. Of special interest of the announcement is a requirement of the Center’s close coordination with efforts to develop new approach methodologies (NAMS) that complement traditional animal-based research. These include cell culture, organoids, computational models, and microphysiological systems. Proposed activities should include collection and analysis of the comparative information on the use of NAMs that enhance the predictive power of human disease models and support their integration with traditional models. The Center should develop an active program for monitoring and collecting information on the impact of the MMRRC consortium’s ongoing activities concerning biomedical research as well as a high risk, high return research pilot that complements the goals and needs of the MMRRC consortium related to informatics services.


Applications are not being solicited at this time. Notice is being provided to allow potential applicants sufficient time to develop meaningful collaborations and responsive projects. This NOFO will utilize the U42 activity code. Investigators with expertise and insights into bioinformatics, animal and non-animal models of human diseases are encouraged to begin to consider applying for this NOFO. In addition, collaborative investigations combining expertise in mouse genetics and biology as well as research databases will be encouraged; these investigators should also begin considering applying for this application.

Eligibility

Eligible applicants

Nonprofit

  • Other Native American tribal organizations
  • Nonprofits non-higher education with 501(c)(3)

Government

  • County governments
  • State governments
  • Federally recognized Native American tribal governments

Business

  • For-profit organizations other than small businesses
  • Small businesses

Education

  • Private institutions of higher education
  • Public and state institutions of higher education

Additional information

Grantor contact information

Description

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Email

oleg.mirochnitchenko@nih.gov

oleg.mirochnitchenko@nih.gov

Documents

No documents are currently available here

Link to additional information

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Forecasted

Estimated Post Date:

June 17, 2025

Estimated Application Due Date:

August 17, 2025

Estimated Due Date Description:

Not available

Estimated Award Date:

June 1, 2026

Estimated Project Start Date:

June 1, 2026

Fiscal Year:

2026

Application process

This site is a work in progress. Go to www.grants.gov to apply, track application status, and subscribe to updates.

Award

$878,000

Program Funding

1

Expected awards

$--

Award Minimum

$--

Award Maximum

Funding opportunity number:

TEMP-30927

Cost sharing or matching requirement:

No

Funding instrument type:

Cooperative agreement

Opportunity Category:

Discretionary

Opportunity Category Explanation:

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Category of Funding Activity:

Health

Category Explanation:

--

History

Version:

1

Forecast posted date:

June 9, 2025

Archive date:

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