Informatics, Coordination and Service Center for the Mutant Mouse Resource and Research Centers (U42 Clinical Trial Not Allowed)
Agency: National Institutes of Health
Assistance Listings: 93.351 -- Research Infrastructure Programs
Last Updated: June 9, 2025
Description
The Office of Research Infrastructure Programs at Division of Program Coordination, Planning and Strategic Initiatives intends to publish a Notice of Funding Opportunity (NOFO) to solicit applications to provide continuing support for the Informatics, Coordination and Service Center (ICSC) unit of the Mutant Mouse Resource and Research Centers (MMRRC) consortium. The U42 mechanism supports projects to develop and assist animal, biological material and new approach methodologies (NAMs) resources to make models of human diseases available to all qualified investigators without regard to the scientific disciplines or disease orientations of their research activities or specifically directed to a categorical program. This Notice is being provided now to allow potential applicants sufficient time to develop meaningful collaborations and responsive projects.
The NOFO will have two application cycles. The NOFO is expected to be published in Spring 2025, with an expected application due date in Summer 2025. Details of the planned NOFO are provided below.
Research Initiative Details
With this intended reissue of the ICSC funding opportunity, ORIP seeks to enhance ICSC contribution to the larger MMRRC consortium by maintaining scientific rigor, transparency, and experimental reproducibility of the biomedical research while improving the quality of the MMRRC consortium’s services for acquisition, evaluation, characterization, cryopreservation, storage, and distribution of mutant mouse strains and related biological materials. Of special interest of the announcement is a requirement of the Center’s close coordination with efforts to develop new approach methodologies (NAMS) that complement traditional animal-based research. These include cell culture, organoids, computational models, and microphysiological systems. Proposed activities should include collection and analysis of the comparative information on the use of NAMs that enhance the predictive power of human disease models and support their integration with traditional models. The Center should develop an active program for monitoring and collecting information on the impact of the MMRRC consortium’s ongoing activities concerning biomedical research as well as a high risk, high return research pilot that complements the goals and needs of the MMRRC consortium related to informatics services.
Applications are not being solicited at this time. Notice is being provided to allow potential applicants sufficient time to develop meaningful collaborations and responsive projects. This NOFO will utilize the U42 activity code. Investigators with expertise and insights into bioinformatics, animal and non-animal models of human diseases are encouraged to begin to consider applying for this NOFO. In addition, collaborative investigations combining expertise in mouse genetics and biology as well as research databases will be encouraged; these investigators should also begin considering applying for this application.
Eligibility
Eligible applicants
Nonprofit
- Other Native American tribal organizations
- Nonprofits non-higher education with 501(c)(3)
Government
- County governments
- State governments
- Federally recognized Native American tribal governments
Business
- For-profit organizations other than small businesses
- Small businesses
Education
- Private institutions of higher education
- Public and state institutions of higher education
Additional information
Grantor contact information
Description
oleg.mirochnitchenko@nih.gov
Documents
No documents are currently available here
Link to additional information
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Forecasted
Estimated Post Date:
June 17, 2025
Estimated Application Due Date:
August 17, 2025
Estimated Due Date Description:
Not available
Estimated Award Date:
June 1, 2026
Estimated Project Start Date:
June 1, 2026
Fiscal Year:
2026
Award
$878,000
Program Funding
1
Expected awards
$--
Award Minimum
$--
Award Maximum
Funding opportunity number:
TEMP-30927
Cost sharing or matching requirement:
Funding instrument type:
Cooperative agreement
Opportunity Category:
Discretionary
Opportunity Category Explanation:
Category of Funding Activity:
Health
Category Explanation:
History
Version:
1
Forecast posted date:
June 9, 2025
Archive date:
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