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DOD Amyotrophic Lateral Sclerosis, Pilot Clinical Trial Award

Agency: Dept. of the Army -- USAMRAA

Assistance Listings: 12.420 -- Military Medical Research and Development

Last Updated: May 23, 2025

Summary: The fiscal year 2025 (FY25) Amyotrophic Lateral Sclerosis Research Program (ALSRP) Pilot Clinical Trial Award supports the rapid implementation of clinical trials with the potential to have a significant impact on the treatment or management of Amyotrophic Lateral Sclerosis (ALS). Projects may range from phase 1 to small-scale phase 2 trials.

 

Applications must address one of the following focus areas:

 

Biomarker-Driven Interventions: Disease-modifying interventions, with mechanism-specific biomarkers to predict which clinical trial participants are likely to respond, demonstrate target engagement, and effects on the intended biological pathway.

 

Clinical Care: Improving aspects of clinical care and symptom management for ALS.

 

Distinctive Features: Funding from this award mechanism must support a clinical trial.

 

Projects proposing a therapeutic intervention (drug, biologic, and/or device) must incorporate biomarkers specific to the intervention into the trial design.

 

All applications are required to incorporate a Community Collaboration Plan, as described in Attachment 8 to optimize research impact.

 

The clinical trial should begin no later than 12 months after the award date or 18 months for FDA-regulated studies.

Eligibility

Eligible applicants

Miscellaneous

  • Unrestricted

Additional information

Grantor contact information

Description

CDMRP Help Desk Phone: 301-682-5507 Email: help@eBRAP.org

Email

CDMRP Help Desk

help@eBRAP.org

Documents

File nameDescriptionLast updated
HT9425FY25ALSRPPCTA_updated.pdf
FY25 ALSRP PCTA Program Announcement
May 23, 2025 12:52 PM UTC

Link to additional information

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Closing: August 27, 2025

Application process

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Award

$5,600,000

Program Funding

2

Expected awards

$--

Award Minimum

$--

Award Maximum

Funding opportunity number:

HT942525ALSRPPCTA

Cost sharing or matching requirement:

No

Funding instrument type:

Grant

Opportunity Category:

Discretionary

Opportunity Category Explanation:

--

Category of Funding Activity:

Science technology and other research and development

Category Explanation:

--

History

Version:

3

Posted date:

April 18, 2025

Archive date:

September 26, 2025

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