DOD Amyotrophic Lateral Sclerosis, Pilot Clinical Trial Award
Agency: Dept. of the Army -- USAMRAA
Assistance Listings: 12.420 -- Military Medical Research and Development
Description
Summary: The fiscal year 2025 (FY25) Amyotrophic Lateral Sclerosis Research Program (ALSRP) Pilot Clinical Trial Award supports the rapid implementation of clinical trials with the potential to have a significant impact on the treatment or management of Amyotrophic Lateral Sclerosis (ALS). Projects may range from phase 1 to small-scale phase 2 trials.
Applications must address one of the following focus areas:
Biomarker-Driven Interventions: Disease-modifying interventions, with mechanism-specific biomarkers to predict which clinical trial participants are likely to respond, demonstrate target engagement, and effects on the intended biological pathway.
Clinical Care: Improving aspects of clinical care and symptom management for ALS.
Distinctive Features: Funding from this award mechanism must support a clinical trial.
Projects proposing a therapeutic intervention (drug, biologic, and/or device) must incorporate biomarkers specific to the intervention into the trial design.
All applications are required to incorporate a Community Collaboration Plan, as described in Attachment 8 to optimize research impact.
The clinical trial should begin no later than 12 months after the award date or 18 months for FDA-regulated studies.
Eligibility
Eligible applicants
Miscellaneous
- Unrestricted
Additional information
Grantor contact information
Description
CDMRP Help Desk
Documents
File name | Description | Last updated |
---|---|---|
HT9425FY25ALSRPPCTA_updated.pdf | FY25 ALSRP PCTA Program Announcement | May 23, 2025 12:52 PM UTC |
Link to additional information
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Closing: August 27, 2025
Award
$5,600,000
Program Funding
2
Expected awards
$--
Award Minimum
$--
Award Maximum
Funding opportunity number:
HT942525ALSRPPCTA
Cost sharing or matching requirement:
Funding instrument type:
Grant
Opportunity Category:
Discretionary
Opportunity Category Explanation:
Category of Funding Activity:
Science technology and other research and development
Category Explanation:
History
Version:
3
Posted date:
April 18, 2025
Archive date:
September 26, 2025