Clinical Coordinating Center for Multi-Site Investigator-Initiated Clinical Trials (Collaborative UG3/UH3 Clinical Trial Required)
Agency: National Institutes of Health
Assistance Listings: 93.839 -- Blood Diseases and Resources Research
93.840 -- Translation and Implementation Science Research for Heart, Lung, Blood Diseases, and Sleep Disorders
93.837 -- Cardiovascular Diseases Research
93.233 -- National Center on Sleep Disorders Research
93.838 -- Lung Diseases Research
Last Updated: May 21, 2025
Description
This Notice of Funding Opportunity (NOFO) supports applications to develop and implement a Clinical Coordinating Center (CCC) for investigator-initiated multi-site clinical trials including efficacy, comparative effectiveness, pragmatic and/or implementation research clinical trials. Trials for which this NOFO applies must be relevant to the research mission of the NHLBI and meet the NIH definition of a clinical trial (see NOT-OD-15-015). For additional information about the mission, strategic vision, and research priorities of the NHLBI, applicants are encouraged to consult the NHLBI website.This NOFO will utilize a bi-phasic, milestone-driven cooperative agreement mechanism of award and runs in parallel with a companion NOFO that encourages applications for a collaborating Data Coordinating Center (PAR-22-193). The objective of the CCC application is to present the scientific rationale for the clinical trial and a comprehensive scientific and operational plan that describes it. The application should address project management, subject recruitment and retention, performance milestones, scientific conduct of the trial, and dissemination of results. Both a CCC application and a collaborating Data Coordinating Center (DCC) application must be submitted on the same application due date for consideration by NHLBI. Applicants are strongly encouraged to contact the appropriate Scientific/Research contact prior to submitting an application.
Eligibility
Eligible applicants
Business
- Small businesses
- For-profit organizations other than small businesses
Government
- State governments
- County governments
- Special district governments
- Federally recognized Native American tribal governments
- Public and Indian housing authorities
- City or township governments
Miscellaneous
- Other
Education
- Private institutions of higher education
- Independent school districts
- Public and state institutions of higher education
Nonprofit
- Nonprofits non-higher education with 501(c)(3)
- Other Native American tribal organizations
- Nonprofits non-higher education without 501(c)(3)
Additional information
Grantor contact information
Description
See Section VII. Agency Contacts within the full opportunity announcement for all other inquires.
Documents
| File name | Description | Last updated |
|---|---|---|
| PAR-25-029-Full-Announcement.html | PAR-25-029 Full Announcement Text | Dec 11, 2024 08:10 PM UTC |
Link to additional information
https://grants.nih.gov/grants/guide/pa-files/PAR-25-029.html
Closing: January 11, 2026
Award
$--
Program Funding
--
Expected awards
$--
Award Floor
$--
Award Ceiling
Funding opportunity number:
PAR-25-029
Cost sharing or matching requirement:
Funding instrument type:
Cooperative agreement
Opportunity Category:
Discretionary
Opportunity Category Explanation:
Category of Funding Activity:
Health
Category Explanation:
History
Version:
2
Posted date:
December 11, 2024
Archive date:
February 10, 2026
