Opportunity Listing - In-Depth Phenotyping and Research Using IMPC-Generated Knockout Mouse Strains Exhibiting Embryonic or Perinatal Lethality or Subviability (R01 Clinical Trial Not Allowed)

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In-Depth Phenotyping and Research Using IMPC-Generated Knockout Mouse Strains Exhibiting Embryonic or Perinatal Lethality or Subviability (R01 Clinical Trial Not Allowed)

Agency: National Institutes of Health

Assistance Listings: 93.865 -- Child Health and Human Development Extramural Research

93.313 -- NIH Office of Research on Women's Health

93.121 -- Oral Diseases and Disorders Research

Last Updated: November 6, 2024

Description

The purpose of this Funding Opportunity Announcement (FOA) is to encourage applications to phenotype and/or perform research on embryonic lethal knockout (KO) mouse strains being generated through the International Mouse Phenotyping Consortium (IMPC) of which the NIH Knockout Mouse Phenotyping Program (KOMP2) is a member. The mission of IMPC is to generate a comprehensive catalogue of mammalian gene function that will provide the foundation for functional analyses of human genetic variation. The current (July 19, 2022) IMPC data release includes phenotypic data for 8260 knockout genes. Overall,...

the IMPC hopes to generate a null mutant and undertake broad-based phenotyping for every gene in the mouse genome. About 30% of these strains are expected to be either embryonic or perinatal lethal, or subviable. However, a large portion of homozygous lethal mutations are expected to have viable heterozygous phenotypes. The scientific community has the unique opportunity to leverage these mouse strains while they are being created and bred as part of the IMPC adult mouse phenotyping effort to perform additional in-depth phenotyping and research.

Eligibility

Eligible applicants

Education

Private institutions of higher education
Public and state institutions of higher education
Independent school districts

Government

Special district governments
Public and Indian housing authorities
County governments
City or township governments
Federally recognized Native American tribal governments
State governments

Miscellaneous

Other

Business

Small businesses
For-profit organizations other than small businesses

Nonprofit

Nonprofits non-higher education with 501(c)(3)
Nonprofits non-higher education without 501(c)(3)
Other Native American tribal organizations

Additional information

Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession.

Grantor contact information

Description

NIH Grants Information grantsinfo@nih.gov

Email

See Section VII. Agency Contacts within the full opportunity announcement for all other inquires.

grantsinfo@nih.gov

Documents

File name	Description	Last updated
PAR-25-140-Full-Announcement.html	PAR-25-140 Full Announcement Text	Nov 6, 2024 05:29 PM UTC

Link to additional information

https://grants.nih.gov/grants/guide/pa-files/PAR-25-140.html

Closing: January 7, 2026

Application process

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Award

$--

Program Funding

Expected awards

$--

Award Floor

$499,999

Award Ceiling

Funding opportunity number:

PAR-25-140

Cost sharing or matching requirement:

Funding instrument type:

Grant

Opportunity Category:

Discretionary

Opportunity Category Explanation:

Category of Funding Activity:

Health

Income security and social services

Category Explanation:

History

Version:

Posted date:

November 6, 2024

Archive date:

February 12, 2026